About Ratio Therapeutics

Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM™ and MACROPA™ platforms: TRILLIUM™ allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA™ simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These enabling platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.

About the Position

Ratio is seeking an Analytical Development Scientist to join our growing team of scientists. In this role, the successful candidate will be responsible for analytical method development. The ideal candidate has a track-record of successful technology development, enjoys working in a collaborative and fast-paced environment, and will seek to maintain trustworthy relationships with interdisciplinary teams at partner organizations.

Key Responsibilities

• Independently develop analytical quality control methods to support advancement of Ratio's lead compounds.
• Act as a main point of contact for technology transfer to CDMO sites as required. Occasional business travel may be required (approximately 5-10%) to facilitate technology transfer activities at CDMO sites.
• Lead drafting, review, and approval of protocols, methods, and relevant IND/IMPD sections.
• Design and perform innovative experiments to support the development of novel radiopharmaceuticals.

Qualifications and Requirements

• PhD in Chemistry or Biochemistry with 4 years of relevant industry and/or academic experience (6 years for MSc, 8 years for BSc).
• Previous experience working with radiopharmaceuticals or radioactive materials is an asset.
• Demonstrated experience in analytical quality control method development (e.g., HPLC, MS, etc.) and advanced theoretical understanding of separation science.
• Detailed working knowledge of cGMP and ICH/FDA guidelines and interest in advancing knowledge in this area.
• Experience with project management (experience managing external CROs or CDMOs is an asset)
• Aptitude in technical writing
• Ability to work effectively in a team environment
• Attention to detail and a quality oriented mindset
• Familiarity and interest in working with radioactive materials
• Open-minded and self-motivating attitude
• Computer skills (Microsoft Office suite)
• Experience in pharmaceutical manufacturing process research and development is an asset.
• Experience working with radioactive materials is an asset.