Duration: 12 months contract
Description:
The growing Genetic Medicine group at South San Fransisco is seeking a highly motivated Associate Scientist to apply cutting-edge technologies to deliver innovative new therapies. As an integral member of the Genetic Medicine Group, this individual will assist in activities related to lipid nanoparticle (LNP)-mRNA production, process development/optimization, and characterization.
The candidate will have familiarity with or prior exposure to laboratory instrumentation/methods related to LNP formulation development, such as microfluidic mixers, dynamic light scattering, membrane-based filtration/dialysis, and fluorescent plate-based assays. The candidate is expected to either show potential in or have hands-on experience to produce and evaluate LNPs with the aim of supporting pipeline projects as well as supporting general laboratory activities. As one of the key team members this individual will work with the manager and scientists across different functional groups to help develop next generation non-viral genetic medicine. The candidate will need to have the ability to clearly present scientific concepts and results.
Responsibilities:
• LNP production, drug delivery system, new assay development.
• Assist in production and characterization of mRNA-LNP formulations to support internal programs.
• Assist in lipid and reagent preparation for manufacturing process as well as aliquoting and accurate labeling for storage and subsequent stability analysis.
• Familiarity with analytical techniques including but not limited to DLS, HPLC, ELISA, SEC, bioconjugation and nucleic acid characterization.
• Work closely with manager and cross-functional team members on multiple projects simultaneously to collect and analyze data on a per project basis.
• Under manager’s supervision, interpret, summarize experimental data, and present experimental results at meetings as needed.
• Assist in ordering supplies and reagents from internal inventory and external vendors necessary to support the projects.
• Generate reliable and reproducible data in a timely manner. Read and adapt scientific literature to accomplish assignments.
• Maintain documentation, databases and laboratory electronic notebooks in compliance with the Company Laboratory Notebook Policy.
• Remain compliant with all departmental and corporate training.
Education and experience:
• BS or MS in Chemistry, Chemical Engineering, Biological Engineering, Pharmaceutical Science or a related field with 0-2+ years of relevant industry experience.
Skills:
• Experience with nanoparticle design and characterization methods is preferred.
• Hands-on experience with nucleic acid characterization and nanoparticle formulation is a plus.
• Hands on experience with chemical conjugation to lipid and analytics is a plus.
• Basic understanding of immunology and cancer biology is a plus.
• Computer skills including Word, Excel, PowerPoint, and relevant scientific software such as Prism.
• Self-motivated, hard-working, detail-oriented, resourceful, and able to work in a fast-paced team environment.
Top skill requirements:
• mRNA-loaded Lipid Nanoparticle Formulation & Characterization experience.
• Techniques such as DLS, HPLC, SEC, RiboGreen.
• Worked with PNI Microfluidic Mixer or Syringe Pump Mixer.
• Performed purification using dialysis cartridges or Amicon centrifuge tubes.
• Chemistry background with lipid synthesis, polymer chemistry for delivery system.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit .
US Tech Solutions is an Equal Opportunity Employer.All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details:
Name: Shivangi
Email:
Internal Id: 24-27742