Details for the position are as follows:

• 6-month contract to start.
• Rate $40 – 60 an hour depending on experience.
• Location Cambridge, MA – 100% onsite

Job Description:

This position offers the opportunity to impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment. We are searching for a dynamic Associate Biology Scientist with experience interrogating cellular and molecular mechanisms as they relate to kinase target pathway modulation, off-target liabilities, and resistance .

• Independently, develop, optimize, and proactively troubleshoot cellular screening assays.
• Responsible for generating, processing, interpreting, and presenting data in cross functional team meetings
• Proactively employ cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action.
• Independently design, execute and document experiments to evaluate target dependency, off target liabilities, phenotypic responses and identifying resistance mechanisms.
• Regularly share and present data with team members.

Required Skills:

• Bachelor’s degree required, MS degree preferred
• Experience in developing and optimizing cell-based assays in multiple platforms (for example CTG, HTRF, AlphaLISA , FC, Jess-WB, NanoBret, Nanostring).
• Experience with different molecular and cellular biology techniques (such as Western Blot).
• Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus.
• Familiar with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models.
• Experience with standard software analytical tools, xlsx, Prism, or other synergy software.