Associate Scientist II

6 month contract to start (benefits offered)

Cambridge, MA

Pay: $38-42 depending on experience

Must be a US citizen or Green Card holder (visas/OPT/C2C not eligible)

Overview:

The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleotides and siRNAs.

Summary of Key Responsibilities:

• Support non-GMP oligonucleotide production on a tight timeline
• Support purification method development, optimization, and scale-up
• Execute non-GMP oligonucleotide purifications
• Execute downstream processing of purified material
• Execute in-process analytical tests
• Participate in creating and reviewing SOPs and batch records
• Support campaign activities across other unit operations as-needed

Qualifications:

• BS in Chemistry with 1-3 years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred. Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.
• Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.
• Good communication skill is a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.