Job Title: Research Associate - Discovery

Employment Status: Full-Time

About Sapience Therapeutics

At Sapience, we think boldly about the possibilities for treating cancer. We aim to discover and develop peptide therapeutics to address oncogenic and immune dysregulation that drive cancer. With in-house discovery capabilities, Sapience has built a pipeline of therapeutic candidates called SPEARs™ (Stabilized Peptides Engineered Against Regulation) that disrupt intracellular protein-protein interactions, enabling targeting of transcription factors which have traditionally been considered undruggable, and can deliver cargo to cell surface targets with their new class of molecule called SPARCs™ (Stabilized Peptides Against Receptors on Cancer), enabling delivery of payloads such as a-particles to cancer cells. Sapience is advancing its lead programs, ST316, a first-in-class antagonist of ß-catenin, and ST101, a first-in-class antagonist of C/EBPß, through Phase 1-2 clinical trials.

Position Summary:

We are seeking a highly motivated and meticulous researcher to support the discovery and characterization of peptide candidates. The ideal candidate will be someone who enjoys working in a collaborative and fast-paced environment. The candidate will be involved in peptide discovery efforts utilizing Sapience’s ADAPT and PADS platforms. The candidate will perform genomic and cell-based assays to support peptide candidate discovery and optimization.

The ideal candidate will demonstrate careful lab practices, attention to detail, and a willingness to learn and practice new techniques. They will be self-motivated, a skilled problem solver, and will have the ability to grow into the role as they gain more experience.

Responsibilities:

• Support duties related to the parallel progress of multiple projects.
• Keep up-to-date and well-organized records of experiments.
• Communicate effectively and transparently.
• Participate in meetings and present their work to the group
• Be able to work collaboratively with a diverse group of people from all backgrounds.
• Perform other related duties as necessary to the proper functioning of the laboratory.
• Collaborate with other team members and the ability to adapt to new priorities.

Requirements:

• A minimum of bachelor’s degree in cell biology, biochemistry, molecular biology, or a closely related field.
• Molecular biology skills such as DNA/RNA isolation, PCR, molecular cloning and vector design and construction, Western blotting, and gel electrophoresis are required.
• Experience with mammalian cell culture, reporter assays, viability assays and flow cytometry is preferred.
• Experience with data analysis using Microsoft Office and Prism.
• Minimum of 1 year industry experience is preferred.
• Time and organizational management skills
• Excellent oral and written communication skills
• Demonstrated ability to collaborate.

What We Offer

• A diverse and inclusive culture where ideas are shared and your authentic self is welcome
• Exceptional, collaborative, dedicated team
• The opportunity to participate in work which may have a transformational impact on patients’ lives
• Continuous learning and dynamic challenges to help you grow and be the best version of yourself
• Comprehensive health/dental/vision insurance, 401k match, stock options, PTO

How to Apply

Please submit your CV and cover letter in PDF format to Please indicate the position title in the subject line of your email. We will contact you should we wish to arrange a meeting to discuss this position further.

Sapience Therapeutics is an equal opportunity employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds.