Job Title: Biophysics Research Associate

Location: 1250 S. Collegeville Road, Collegeville, PA 19426

Hours: 40 hours/week, Monday to Friday, 8:00 AM – 5:00 PM (flexible schedule)

Position Overview:

We are seeking a motivated Scientific Service Specialist 1 to join the Biophysics group within our R&D team in Upper Providence, PA. This role involves generating and analyzing biophysical assay data to support drug discovery efforts, specifically focusing on protein characterization and protein-ligand binding analysis. The ideal candidate will work closely with protein biochemists and structural biologists, contributing to high-quality data generation and supporting the transformation of data acquisition and integration within the team.

Daily Responsibilities:

• Conduct biophysical assays and data analysis to support the drug discovery pipeline, including protein characterization and protein-ligand binding assays.
• Work in a matrix team environment, collaborating with cross-functional business partners to achieve project objectives.
• Organize, interpret, and present experimental results at group meetings.
• Perform routine laboratory maintenance and ensure compliance with safety protocols and ethical standards.
• Maintain an electronic laboratory notebook to document experiments and results.
• Ensure proper inventory management by routinely checking and maintaining laboratory supplies.
• Follow detailed protocols and maintain high standards of notetaking and data documentation.
• Ensure compliance with all R&D data integrity practices, safety codes, and environmental regulations.

Working Environment:

• Work will be primarily in a laboratory setting, with potential exposure to hazardous materials, requiring the use of personal protective equipment (PPE).
• The job pace may be fast, with high demands for job completion.
• Employee may be required to manage hazardous waste in compliance with company and regulatory standards.

Skills and Qualifications:

• Education: BS in a life sciences discipline (e.g., biophysics, analytical chemistry, biochemistry).
• Experience: Laboratory research experience, preferably in quantitative or analytical sciences.

Technical Skills:

• Strong practical knowledge of protein biochemistry and biophysics.
• Experience with biophysical analysis techniques such as thermal stability analysis, microscale thermophoresis, surface plasmon resonance, and hydrogen deuterium exchange mass spectrometry is highly desirable.
• Proficiency in curve fitting, regression analysis, mathematical modeling, or other quantitative data analysis techniques.
• Familiarity with working with purified proteins for biophysical analysis, enzymology, or structural biology.
• Additional Skills:
• Ability to handle, store, label, and ensure the safety of scientific materials and data.
• Strong communication skills with the ability to summarize and present findings to a varied audience.
• Strong data handling skills, including acquisition, manipulation, and documentation of experimental data.

Physical Demands:

• Ability to remain stationary for more than 25% of the time.
• Regular movement within the lab, including bending, squatting, and reaching for instruments or materials.
• Must be able to lift and move up to 25 pounds regularly, and occasionally up to 100 pounds.
• Specific vision abilities required include close-range observation, distance vision, color vision, peripheral vision, depth perception, and the ability to adjust focus for detailed work with instruments.

Success/Performance Metrics:

• Successful completion of assigned biophysical assays with high accuracy and timely delivery of data.
• Effective collaboration with cross-functional teams to achieve project objectives.
• Clear, concise communication of experimental results and findings to both technical and non-technical audiences.

Soft Skills:

• Strong communication skills, both written and verbal.
• Proficient in scientific data handling, including acquisition, manipulation, and visualization of experimental data.
• Ability to work independently and as part of a collaborative team.