Job DescriptionPosition Summary:The Structural Biology and Biophysics group at Vertex Pharmaceuticals is responsible for generating reagents as well as biophysical and structural information that is critical for the advancement of research programs to create transformative medicines for patients with serious diseases. The group is seeking a highly motivated and collaborative Principal Research Scientist with significant experience utilizing biophysical methods and CryoEM for structure-based drug design to help guide these efforts. The ideal candidate for this lab-based role will possess excellent technical skills in sample handling for biophysical studies of small molecule ligand binding and utilization of CryoEM, a proven track record in drug discovery, strong communication skills, and the ability to collaborate with members of an interdisciplinary project team.Key Duties and Responsibilities:Work within drug discovery project teams to design and execute biophysical experiments that answer key questions and aid in molecular designDevelop and execute ligand binding studies using Surface Plasmon Resonance (SPR), Thermal Shift Analysis (TSA), Isothermal Titration Calorimetry (ITC)Design and generation of reagents for biophysical studiesDetermine structures using CryoEM and application for structure-based designSample preparation, execution of experiments, and organized reporting of resultsKeep up to date with the scientific literature in the field and beyondActively participate in group and cross-disciplinary project team meetingsPresent results to project teams in a clear and understandable wayKnowledge and Skills:Significant experience working with integrated drug discovery teams utilizing structure-based drug design.Deep understanding of biophysical and structural methodsAbility to develop and execute biophysical assays to measure ligand bindingExperience with CryoEM data collection, structure determination, and analysisExperience with hit-to-lead activitiesTrack record of productivity as evidenced by a strong publication recordSelf-motivation, organization, and ability to communicate effectively with project teamsEducation and Experience:Ph.D. (or equivalent degree) in biological science and 4-7 years of relevant post-doctoral employment experience, orMasters Degree (or equivalent degree) in biological science and 7+ years of relevant employment experience, orBachelors Degree (or equivalent degree) in biological science and 10+ years of relevant employment experienceFlex Designation:On-Site DesignatedFlex Eligibility Status:In this

On-Site

designated role, you will work

five days per week on-site

with ad hoc flexibility.Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

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