Position Summary

We are looking for a Scientist/Senior Scientist, Translational Research (contractor) with a strong background in Translational Immunology to join our team. The ideal candidate will be a highly motivated and creative scientist with deep expertise in autoimmune and inflammatory diseases and hands-on experience with in vitro/ex vivo primary cell-based assays and in vivo animal models. You will play an integral role in forward and reverse translational research in a highly matrixed team environment that will guide the preclinical to clinical development of novel IgM-based therapeutics. Extensive experience in multi-parameter flow cytometry is a must. This role will require up to 50% laboratory work.

Responsibilities:

1. Develop, qualify, and implement methods to evaluate drug mechanisms of action and differentiation to competitor molecules and to identify candidate pharmacodynamic and predictive biomarkers in nonclinical in vitro and in vivo models of autoimmune and inflammatory diseases
2. Integrate and interpret preclinical biomarker data for successful cross-functional transfer to clinical biomarker colleagues
3. Prepare or draft preclinical research reports and preclinical IND sections, regulatory filings
4. Work closely with research and clinical collaborators and CROs
5. Accountable for forward and reverse translational research strategy, data delivery, and communication, and adhering to timelines
6. Presentation of results at internal and external meetings
7. May train and supervise direct reports

Qualifications

1. Level commensurate with experience.
2. Degree in Immunology/Pharmacology or a related scientific discipline. PhD highly preferred.
3. For Sr. Scientist level we're looking for 7+ years of industry experience with PhD or MS with 10+ years, or industry experience.
4. Substantial expertise in translational immunology research, is highly desirable.
5. Proven track record of preclinical biomarker assay development, qualification, and implementation.
6. Understanding of and ability to select and execute relevant nonclinical in vitro assays and in vivo models for mechanistic and biomarker studies
7. Expertise with high dimensional flow cytometry (16+ parameters), genomic and proteomic expression analyses, and NGS and single-cell RNA-Seq protocols
8. Experience with exploratory clinical sample assays and analysis is a plus
9. Initiate, propose, plan, and manage studies at external CROs and data interpretation
10. Able to thrive in a fast-paced, start-up environment
11. Able to commute to Mountain View