Scientist, Analytical Chemistry

South San Francisco, CA

Our client is at the forefront of developing a non-viral gene therapy platform capable of precisely targeting various organs in the body, delivering large payloads in multiple formats without the need for invasive procedures.

We are looking for a scientist with strong mass spectrometry and chromatography expertise to develop assays in support of gene therapy programs.

Qualifications:

• Ph.D. with 2+ years or M.S. with 6+ years of industry experience in analytical chemistry, chemical biology, biochemistry or a related field.
• Creativity and the ability to work within an interdisciplinary team to achieve technical and corporate milestones.
• Ability to thrive in a fast-paced, start-up environment.
• Strong verbal and written communication, critical thinking, and problem-solving skills.

Technical Requirements and Skills:

• Extensive expertise in the development of analytical assays to support drug product characterization, including LC/UV, LC/MS, CE, and biochemical readouts.
• Successful development of proteomic and metabolic assays is preferred.
• Knowledge of purification with different chromatography methods including HPLC, IEX, and SEC for protein conjugations.
• Previous experience using state-of-the-art LC-MS equipment for MRM/SRM and TOF analysis (Shimadzu, Agilent, Waters, ExionLC AE, Sciex).
• Analyze proteomics data using proteomics analysis software (Skyline) and bioinformatics tools for protein and peptide quantification.
• Working knowledge with recombinant protein downstream purification and characterization.
• Research literature and external sources and identify new techniques and procedures.
• Ideal candidate will have familiarity with ELNs (i.e. Benchling), Olink-based proteomics, MSD, Western blot, metabolomics and unbiased proteomics analysis.

Compensation: The salary range for this position is $125,000.00 to $150,000.00 USD annually.