Job Description:

We are seeking a highly skilled and motivated Scientist with a strong background in synthetic chemistry, peptide chemistry and solid-phase peptide synthesis. This role is primarily lab-based, focused on design, synthesis and biochemical characterization of preclinical compounds for oncology applications. If you are a skilled and enthusiastic chemist, eager to contribute to the discovery of novel therapeutics, we encourage you to apply and become a part of our team.

Key Responsibilities:

• Design, synthesize, purify, and characterize peptide starting materials that will serve as building blocks for our proprietary Precision-Linked Proteomimetics.
• Characterize compounds using analytical methods including HPLC, LC-MS, NMR and other relevant analytical methods.
• Conduct biochemical assays to determine target-binding potency of starting-point peptides and PLP compounds.
• Execute experimental plans, troubleshoot synthetic challenges, and optimize peptide characteristics (physicochemical properties, target binding, etc.).

Required Skills and Experience:

• Ph.D. with 2+ years of industry/postdoctoral experience or MS with 3+ year of industrial experience in a relevant scientific field (Chemistry, Biochemistry, Medicinal Chemistry, etc.) with a strong academic track record.
• High degree of proficiency in synthetic organic chemistry with experience in peptide chemistry and solid-phase peptide synthesis.
• Experienced with compound purification and characterization methods such as HPLC, LC-MS, NMR, and MALDI.
• Experience with peptide design, including SAR studies and optimization.
• Expertise in in vitro biochemical assay design and execution (SPR, BLI, TR-FRET, MST, etc.).
• Experience applying computational methods to designing compounds is a plus.
• Knowledge of automation and validation of assays for HTS is a plus.
• Strong commitment to a lab-based role, with a high level of comfort working in a hands-on capacity in a synthetic chemistry environment

Strong organizational skills and attention to detail, with the ability to manage multiple tasks and maintain accurate records of experimental work

• Excellent teamwork and communication skills, with the ability to work effectively with senior scientists and contribute to a collaborative research environment