Job Description:

Support RNA assay development and chemistry by supporting RNA extraction, qPCR, immunoassays, and analytical methods to characterize oligonucleotides.

Responsibilities:

• Responsible for conducting research in assigned areas under direct supervision using established methodology.
• Plans and conducts moderately complex experiments and analyzes and interprets the results. Keeps accurate records of work undertaken.
• Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to characterize and screen siRNA oligonucleotides
• Support siRNA characterization by through routine and consistent performance of 4 or more assays
• Support lipid nanoparticle (LNP) development and characterization using dynamic light scattering (DLS), Encapsulation efficiencies (ribogreen fluorescence) and HPLC.
• Support routine tasks associated with siRNA solid phase supported synthesis and characterization using LC/MS.
• Collect and evaluate data; prepare reports, summaries, and presentations; maintain and update laboratory notebook and the laboratory information management system
• Manage inventory of supplies, ordering reagents and consumables.

Qualifications:

• Experience with RNA extraction and qPCR.
• Experience in analytical methods to characterize oligonucleotides.