Job Details:

Job Title: Scientist 2 - Research and Development / Assay Development Scientist / Oligonucleotides Discovery Scientist

Duration: 12 months Contract on W2

Location: San Diego, CA 92121

Notes from HM:

• Role will be Onsite in San Diego, CA
• Bachelor Degree in Science is required
• Must have exp in Laboratory
• Will support multiple groups including Chemistry group
• Must have Assay experience and knowledge
• Experience with QPCR (experience in one or a couple of these areas would be ideal)
• Knowledge with therapies, RNAs
• RNA extractions
• LC/MS experience
• Reviewing concentration readings
• Lipid nanoparticle (LNP) exp
• Oligonucleotides experience
• Electronic Lab notebook exp

Description:

Support RNA assay development and chemistry by supporting RNA extraction, qPCR, immunoassays, and analytical methods to characterize oligonucleotides

Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to characterize and screen siRNA oligonucleotides

Support siRNA characterization by through routine and consistent performance of 4 or more assays

Support lipid nanoparticle (LNP) development and characterization using dynamic light scattering (DLS), Encapsulation efficiencies (ribogreen fluorescence) and HPLC.

Support routine tasks associated with siRNA solid phase supported synthesis and characterization using LC/MS.

Collect and evaluate data; prepare reports, summaries, and presentations; maintain and update laboratory notebook and the laboratory information management system

Manage inventory of supplies, ordering reagents and consumables

General Summary: Responsible for conducting research in assigned areas under direct supervision using established methodology.

Duties & Responsibilities: Plans and conducts moderately complex experiments and analyzes and interprets the results. Keeps accurate records of work undertaken.

Top Three Skills: RNA extraction, qPCR, Experience in analytical methods to characterize oligonucleotides.