Principal Scientist, Immune-Oncology

Canton (Greater Boston), MA

Full time

Job Description:

We seek an innovative and dynamic principal scientist to spearhead protein and antibody engineering efforts within our Rapid Response Group (RRG), a specialized team in our Discovery Division. The RRG operates with a hands-on, mission-focused approach, parachuting into high-impact projects to develop critical tools, methodologies, and data that enhance our therapeutic programs. The successful candidate will be a key member of this elite team, driving research on protein targets and therapeutic development. They are able to effectively balance high-level scientific ideation with hands-on execution at the bench. This role is crucial to our R&D mission, directly influencing our success; In this role, you will take full ownership of high-impact projects, ensuring their success by leveraging your expertise, creativity, and resilience.

Key Responsibilities:

• Manage all aspects of selection, design, and optimization of fusion proteins and antibodies in different formats to optimize their function
• Spearhead the conceptualization, design, and cloning of innovative bispecific or similar multi-specific antibody formats, including dual/multi-targeting capabilities.
• Coordinate small- and large-scale protein expression, specifically in insect and mammalian cells, and maintain eukaryotic cells for all users in the team
• Lead design, implementation, and troubleshooting of novel purification protocols to address technical challenges and produce high-quality protein
• Oversee development and optimization of assays to screen and test function and affinity of antibodies and recombinant proteins
• Synthesize data to clearly communicate progress and status in weekly/biweekly lab meetings, ensuring adherence to timelines in a dynamic, fast-paced environment.
• Provide thoughtful leadership and mentorship to junior RRG team members, encouraging collaboration and productivity across the group
• Collaborate cross-functionally with immuno-oncology, virology, and structural biology
• teams, sharing expertise to enhance our ability to work with a diverse family of proteins.

Qualifications :

• PhD in Molecular Biology, Biophysics, Structural Biology, Biochemistry, Cell Biology, or related disciplines; exceptional MS candidates will be considered.
• 6-8 years of relevant experience in a dynamic, fast-paced environment; 3-5 years of industry experience preferred.
• Strong track record of critical thinking and scientific achievement as demonstrated by publications in scientific journals.
• Familiarity with various antibody formats and scaffolds including, but not limited to, fusion proteins, bi/tri-specific antibodies, single-domain antibodies (VHH), and bi-paratopic antibodies
• State-of-the-art expertise in designing and building innovative protein therapeutics having the intended mechanisms of action and meeting the target product profile
• Skilled practitioner in protein structure-based design and engineering, proficient in utilizing protein sequence and structure-based tools and techniques
• Demonstrated expertise in protein biochemistry including protein expression, purification, and assessment of protein biophysical properties.
• Working knowledge in biologics expression, purification, functional screening assays, and developability assessments
• Excellent troubleshooting skills, strong analytical abilities, meticulous attention to detail, and exceptional organizational skills.
• Excellent work ethic and adaptability, with the ability to multitask and maintain a “can-do” attitude as R&D priorities shift.
• Strong interpersonal skills including verbal and written communication to work effectively within a collaborative work environment.

Job Type: Full-time, Work Permit, Equal Opportunity Employment. If you are interested send us your CV /Resume and a note to our recruiting team.