Research Scientist

6-month contract

Onsite in Lexington, MA

Overview:

As a Research Scientist in the Nucleic Acid Delivery, Formulations & Bioanalysis overall department, you will join a multinational and diverse team of Reseach Associates, specialists/Scientists. The goal of the team is to develop preclinical formulations of conjugated oligonucleotides apply advanced analytical characterization techniques and translate these to preclinical and clinical studies through internal and external collaborations in an automated high throughput manner.

Responsibilities:

• Identifies gaps in technological capabilities provides recommendations to guide the research agenda

• Manage multiple external collaborations for deliverables

• Optimize long-term storage and stability conditions of RNAi conjugates and oligonucleotide formulations in general

• Develop robust analytical methods and assays for QC and developability assessments

• Communicate findings internally to team via presentations and written reports

• Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines

Qualifications:

• 3 years of relevant experience with a PHD (LEVEL II) or 3+ years of relevant experience with a Masters (LEVEL I)

• Subject matter expertise in Pharmaceutical Sciences, oligonucleotide/peptide/antibody characterization, or related scientific disciplines

• In-depth and hands-on experience in a range of synthesis, characterization, and purification techniques, including but not limited to NMR, HPLC (analytical and preparative), Mass Spectrometry, IR, silica gel and reverse phase chromatography, TLC, recrystallization etc.

• Acting as formulation subject matter expert for nucleic acid therapeutics.

• Ability to establish screening assays for oligonucleotides in early discovery.

• Experience with analytical method development for solubility, viscosity, degradation and rheological assessment for complex oligonucleotides

**compensation based on experience**